Mad Scientist is a type of profession that can only be spliced during the Cover of Darkness.
- Mad Scientist + Bell Ringer = Henchman
- Mad Scientist + Henchman = Monster
- Mad Scientist + Super Hero = Supervillian
- The male version of the Mad Scientist, producing 3 cps, resembles Dr. Emmett Brown from Back to the Future.
- The names reference the novel Frankenstein. The male name refers to the title character, and the female name refers to the author, Mary Shelley.
- The female 3 cps version resembles Mary Test from the show "Johnny Test".